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Moreover, it has been shown that a GLP-1R agonist attenuated ER stress by downregulating ATF-4, a biomarker of ER stress, and inhibited apoptosis in INS-1 β-cells, which could improve cell survival 43
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'We hope to go into this market not just to reduce the weight of patients who struggle with obesity, but also to help deliver on the medical benefit of managing that weight.'⁶ For Amgen, everything now hinges on the results of those phase 3 trials
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